MAPT and early-onset autosomal dominant Alzheimer disease: Conversely, the Tau Hypothesis establishes that abnormalities in tau protein, such as hyperphosphorylation and subsequent aggregation into neurofibrillary tangles, are the central pathogenic events in Alzheimer’s disease (Maccioni et al., 2009, 2010; Crespo-Biel et al., 2012).