DNM1L and acute kidney injury: Honokiol also mitigates oxidative stress by reducing reactive oxygen species (ROS) and enhancing antioxidant enzyme activity in renal epithelial cells.32 Honokiol has also been shown to protect against cisplatin-induced acute kidney injury in animal models by modulating mitochondrial fission and regulating key proteins such as dynamin-related protein 1 (DRP1)33 and sirtuin 3.34 Moreover, honokiol enhances therapeutic responses when combined with carboplatin and gemcitabine in docetaxelresistant tumors.19