Its renoprotective activities are via the RhoA/Rho‐associated coiled‐coil‐containing kinase signaling pathway, suppressing renal fibrosis in HG‐induced glomerular MCs (72), upregulating Janus Kinase‐2 (JAK2)/STAT3 and Nrf‐2/HO‐1 (Kaabi 2022), TGF‐β1/Smad/ECM, and TGF‐β1/CTGF/ECM signaling cascades (Parveen et al. 2018). The gene discussed is CCN2; the disease is renal fibrosis.