It also lowered fasting blood glucose, serum creatinine, blood urea nitrogen, MDA, proteinuria, IL‐6, TNF‐α, IL‐1β, and NF‐κB; elevated GSH‐Px, CAT, Bcl‐2, chemokine receptors, SOD, Nrf2, and HO‐1 levels in different STZ‐induced DKD diabetic models. Here, HMOX1 is linked to diabetic kidney disease.