The same study documented a significant ameliorative effect of curcumin in STZ‐induced DKD rats by regulating albumin/protein urea and increasing creatinine clearance, which involved activation of Nrf2, inhibition of NF‐κB, NADPH oxidase, and significant upregulation of the PKCβII/p66Shc signal. Here, NFKB1 is linked to diabetic kidney disease.