In conclusion, this pilot study suggests that the presence of both obesity and persistent elevated serum ALT levels is associated with increased fecal SCFA concentrations and SCFA-producing bacteria, particularly Roseburia. However, a larger sample is required to define whether the associations of SCFA fecal levels with obesity and elevated ALT levels are independent. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.