Subsequentsteps in fructose metabolism contribute to the accumulation of palmiticacid and ceramide, which are implicated in age-related diseases suchas cancer, type 2 diabetes, neurodegeneration, and cardiovasculardisorders. Ceramide accumulation exacerbatesmitochondrial dysfunction and disrupts protein homeostasis, acceleratingtissue aging. Our current data presentedhere demonstrate a clear correlation between increased ceramide levelsand elevated senescence markers (p53, p21, SASP). The gene discussed is CDKN1A; the disease is type 2 diabetes mellitus.