Dysregulation of Wnt/β-catenin signaling can leadto an imbalance of normal cellular physiology and is implicated ina variety of diseases including cancer., Consequently,pharmacological modulation of Wnt signaling has emerged as an attractiveapproach for therapeutic applications, including tissue regeneration and cancer treatment. Wnt signaling is initiated at the plasma membrane, where a ternarycomplex is formed between Wnt ligands and their cell surface receptors,Frizzled and low-density lipoprotein receptor-related protein 5/6(LRP5/6). This evidence concerns the gene LRP5 and cancer.