This interaction initiates clearanceof these E3 ligases from the membrane, ultimately enhancing Wnt signaling.RNF43 contains a protease-associated domain, a transmembrane region,and a cytoplasmic really interesting new gene (RING) domain that isresponsible for its E3 ligase function. The pivotal role of the RNF43 in cancer has been established acrossvarious forms of cancers. Inactivatingmutations of RNF43 have been identified in colorectal cancer, pancreaticductal adenocarcinoma and endometrial cancer,, underscoring its significance in oncogenesis. Here, RNF43 is linked to endometrial cancer.