RNF43 and neoplasm: The Wnt/β-cateninpathway is critical in humantumor progression.Cell-surface transmembrane E3 ubiquitin ligase ring finger 43 negativelyregulates Wnt signaling through ubiquitination of Wnt coreceptor Frizzled.Aberrant Wnt signaling through inactivating mutations of RNF43 hasbeen identified in various forms of cancers, highlighting its significancein tumor biology.