In the T cell-driven SKG mousemodel of RA, combination CTLA-4 IgG and Agg-CLNP significantly enhanceddisease onset in prearthritic SKG mice compared to abatacept alone.In a dexamethasone (Dex) withdrawal flare model in SKG mice, Agg-CLNPreduced recurrent flare severity when administered. The gene discussed is CTLA4; the disease is rheumatoid arthritis.