SKG mice are well poised to model high risk patients,as these mice are genetically predisposed to develop RA post mannaninjection and older SKG mice have been shown to naturally developRA., Therefore, we injected SKG mice with CTLA-4IgG or a combination of CTLA-4 IgG with Agg-CLNP at the time of RAsynchronization and for two more days thereafter. This evidence concerns the gene CTLA4 and rheumatoid arthritis.