In PCM, by contrast, the IL-6/JAK/STAT3/plasma cell axis is central: plasma cells not only secrete IL-6 to fuel inflammation but also contribute to ECM remodeling via matrix-degrading enzymes, and activate Bcl-2 to promote their survival, thereby enhancing fibrosis (22, 38, 45). The gene discussed is BCL2; the disease is paracoccidioidomycosis.