DNASE1 and colorectal carcinoma: (12) designed a plasmonic core black-body gold (AuPB) nanoplatform with a broad spectrum of photoactivity and a mesoporous polydopamine (mPDA) coating for efficient loading and photo-regulated release of DNase I. The on-demand DNase I released by the mechanism triggered by a second near-infrared light irradiation (NIR-II) breaks down the barrier formed by NETs, thereby increasing the contact of immune cytotoxic cells with tumor cells in living mice and sensitizing CRC to immune checkpoint therapy.