(12) designed a plasmonic core black-body gold (AuPB) nanoplatform with a broad spectrum of photoactivity and a mesoporous polydopamine (mPDA) coating for efficient loading and photo-regulated release of DNase I. The on-demand DNase I released by the mechanism triggered by a second near-infrared light irradiation (NIR-II) breaks down the barrier formed by NETs, thereby increasing the contact of immune cytotoxic cells with tumor cells in living mice and sensitizing CRC to immune checkpoint therapy. The gene discussed is DNASE1; the disease is neoplasm.