(141) mice with colorectal cancer treated with DNase I after injection of lipopolysaccharide (LPS) to stimulate NETs formation showed significantly less metastasis compared to mice treated with LPS alone, which was also associated with a decrease in the expression of TLR9, p-p38, p-p65, p-JNK and p-Stat, and the same effect could be observed after using the PAD4 inhibitor YW4-03 (141). The gene discussed is DNASE1L3; the disease is colorectal cancer.