Furthermore, it was revealed that YAP phosphorylation in podocytes was involved in the pathogenesis of diabetic nephropathy by decreasing the expression of transcriptional factor Wilms’ tumor 1 (WT-1) and WT-1-regulated proteins, including nephrin and podocalyxin, all of which are indispensable for podocyte function (6). This evidence concerns the gene WT1 and diabetic kidney disease.