Extracellular ATP activates the P2X7 receptor on Mφ surface, inducing NLRP3 inflammasome-dependent IL - 1β release and upregulating the expression of MHC-II molecules and costimulatory molecules CD80/CD86, thereby promoting the cross-presentation of tumor antigens to CD4+ T cells (21, 22). Here, P2RX7 is linked to neoplasm.