At the level of epigenetic regulation, m6A modification-related RBPs form a cascading regulatory network: methyltransferase METTL3 enhances m6A modification on CBX4 mRNA—the oncogene—thereby improving its stability which leads to upregulation of matrix metalloproteinases MMP2/MMP9 as well as mesenchymal marker N-Cadherin promoting tumor metastasis (59). This evidence concerns the gene MMP9 and neoplasm.