Paradoxically, in ethylene glycol-induced rat models of Calcium Oxalate Nephrolithiasis, elevated IL-6 levels exhibit significant positive correlation with oxidative stress marker 8-OHdG, implicating its role in promoting crystal deposition through ROS-mediated cascades (23) (Figure 1). Here, IL6 is linked to nephrolithiasis susceptibility caused by SLC26A1.