CXCL14 and nephrolithiasis: In contrast, CXCL14—elevated in high-fat diet murine models—induces macrophage M2 polarization, enhancing phagocytic clearance of crystals on bladder epithelial surfaces and thereby inhibiting pathological stone progression (72), this finding highlights CXCL14 as a promising target for Calcium Oxalate Nephrolithiasis research.