To confirm whether SEMA7A plays a key role in NSCLC tumor progression, siRNAs were used to silence the SEMA7A gene in the mouse NSCLC cell line LLC and the human NSCLC cell line H1299 (Supplementary Figures 1A, B), which have relatively high SEMA7A expression at both the mRNA and protein levels (Figure 2A). This evidence concerns the gene SEMA7A and neoplasm.