Zhang ‘s team confirmed in bladder cancer that platinum-based chemotherapy synergistically promotes TLS regeneration and maturation by inducing tumor immunogenic death to release antigens, activating dendritic cells, and combining programmed cell death 1/programmed cell death ligand 1(PD - 1/PD-L1) inhibitors (22). This evidence concerns the gene PDCD1 and urinary bladder carcinoma.