In patients with advanced RA, the level of phosphatidylserine (PS 36:1) in synovial fluid increased by 3.2 times, and the secretion of TNF-α was increased by 2.8 times by activating TLR4 pathway, while the inflammation score of experimental arthritis model was reduced by targeting phospholipid flipper Xkr8 (78, 82). The gene discussed is TNF; the disease is rheumatoid arthritis.