IFNG and neoplasm: To identify the local and systemic immune effectors involved in the immunomodulatory property of OpdA, we analyzed the production of IFN-γ and IL-10 in mice treated with active and inactivated protease at the lung metastatic site, in serum, and by tumor-specific T lymphocytes in splenocyte and lymph node cell populations after ex vivo re-stimulation with tumor antigens.