Since an almost total suppression of CD8-mediated cytolytic activity is primarily reliant on TGFβ-signaling, and CD8+ T cells with a dominant negative TGFβ receptor were resistant to this suppression, and CD8+ T cells with a dominant negative TGFβ receptor were resistant to this suppression, TGFβ secretion from Treg cells can regulate CTL function and reduce anti-tumor immunity (105). The gene discussed is CD8A; the disease is neoplasm.