Multiple studies have shown that tumor-associated macrophages can secrete various cytokines, such as platelet-derived growth factor (PDGF), TGFβ1, hepatocyte growth factor (HGF), epidermal growth factor (EGF) family, and basic fibroblast growth factor (BFGF), that facilitate tumor cell proliferation and survival (123). The gene discussed is EGF; the disease is neoplasm.