Fucoidan was able to ameliorate chronic colitis by promoting intestinal IL-22 expression, upregulating colonic IL-22 and fucosyltransferase 2 (FUT2) expression, and inducing IL-22 release from CD4+ T cells through the AhR pathway as well as IL-22 secretion by ILCs, thereby ameliorating luminal and mucosal flora disorders in the small intestine and colon (90). This evidence concerns the gene IL22 and Chronic colitis.