AHR and colitis: In TNBS-induced colitis in humanized mice, the nontoxic AHR agonist methyl 2-(1’H-indole-3’-carbonyl)-thiazole-4-carboxylate (ITE) induced functional human Tregs, which inhibited effector T-cell proliferation in vitro in a CD39- and granzyme B-dependent manner, leading to the up-regulation of IL-22.