The 2,4,6-Trinitrobenzolsulfonic acid (TNBS)-induced mouse model can mimic multiple pathological traits of Crohn disease, and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant that mainly affects the human body through diet, can alleviate colon inflammation in the TNBS colitis mouse model by partially producing regulatory immune cells after activating AhR (111). The gene discussed is AHR; the disease is colitis.