The “gut-liver axis” is one of the key factors in the pathogenesis of NAFLD, transporting intestinal microbial metabolites and inflammatory mediators to the liver via the portal vein, and the AhR may be indirectly involved in the regulation of NAFLD by influencing the composition of the gut microbiota (134). The gene discussed is AHR; the disease is metabolic dysfunction-associated steatotic liver disease.