Although SKA2 had been identified as a GR interactor in peripheral dividing cells (Rice et al., 2008) and had been associated with stress-related psychiatric disorders including PTSD and suicide risk (Sadeh et al., 2016a, 2016b; Kaminsky et al., 2015; Boks et al., 2016; Pandey et al., 2016), its function in nonreplicating, postmitotic neurons, and its potential role in regulating HPA axis activity, had remained unexplored. This evidence concerns the gene NR3C1 and psychiatric disorder.