In the RA group, a comparison using simple regression analysis between the N/L group and the M/H group showed that ESR (p=0.001), CRP (p=0.002), ACPA (p=0.004), duration of bDMARDs (p=0.013), history of bDMARDs (p=0.03), RF (p=0.037), and antidepressant use (p=0.04) were higher in the M/H group (Table 4). There was no significant difference in NRS and PDQ scores. This evidence concerns the gene CRP and rheumatoid arthritis.