For instance, POSTN short fragment with exon 17 promotes EMT and metastasis (Ikeda-Iwabu et al., 2021), while POSTN exon 21 antibodies inhibit tumor cell growth by reducing macrophage M2 polarization and the number of tumor blood vessels in triple-negative breast cancer (Fujikawa et al., 2021). This evidence concerns the gene POSTN and triple-negative breast carcinoma.