Notch1 associates with these RBPJ binding sites after activation in liver bile duct carcinoma cells, and this interaction may promote Notch1-mediated regulation of POSTN transcription, as the Notch1/RBPJ complex is known to control cell fate decisions, proliferation, and differentiation in cancer (Kongkavitoon et al., 2018). Here, RBPJ is linked to cancer.