POSTN and neoplasm: High expression of POSTN is associated with tumor nodules, microvascular invasion, edmodson grade, and tumor-lymph node-metastasis (TNM) stage, affecting the prognosis of patients and decreasing overall survival (Chen et al., 2017; Lv et al., 2013a; Riener et al., 2010; Jang et al., 2016).