Given their diverse biological functions, CHGA and its derived peptides have been implicated in a wide array of diseases, including cardiovascular conditions, hypertension, type 2 diabetes, cancer, and chronic inflammatory disorders (Helle et al., 2007; D’Amico et al., 2014; Tota et al., 2014; Corti et al., 2018; Mahata and Corti, 2019; Watanabe, 2021; Herold et al., 2018; Zalewska et al., 2022). This evidence concerns the gene CHGA and Hypertension.