A report from Colombia found that individuals with the p. Cys455Arg mutation exhibited ligand-induced NOTCH3 signaling was severely reduced and an early-onset CADASIL phenotype (including early-onset stroke and extensive MRI abnormalities), which may be related to the attenuation of Jagged-1-induced NOTCH3 receptor signaling through RBP-Jk by the p. Cys455Arg mutation (30). This evidence concerns the gene NOTCH3 and stroke disorder.