A recent large cohort study not only confirmed the finding that pathogenic variants in EGFr 7–34 cause a milder clinical phenotype than pathogenic variants in EGFr 1–6, but further found that the severity of stroke was similar in EGFr 1–9 and 18–34, and that patients with variants in EGFr 10–17 had a lower risk of stroke than those with EGFr 3–4 (35). The gene discussed is EGFR; the disease is stroke disorder.