Furthermore, genome-wide association studies (GWAS) have identified loci such as 9p21, PITX2, ZFHX3, FOXF2, and GUCY1A3 as significant contributors to stroke risk and subtype differentiation, underscoring the interplay of genetic, metabolic, and demographic factors in stroke etiology (227). The gene discussed is ZFHX3; the disease is Stroke.