In multimodal MRI, the imaging histology model incorporating T2WI, ADC and dynamic contrast enhancement (DCE) sequences had a predictive efficacy of AUC 0.95 for HER-2 expression status, and after combining with the BI-RADS score, the AUC for BC diagnosis was elevated to 0.98, which provided a new method for non-invasive preoperative assessment (37). This evidence concerns the gene ERBB2 and breast cancer.