In TEAE analysis, the PC group showed higher occurrence of any grade nausea, alopecia, plateletcount decreased, fatigue, alanine ALT increased, AST increased, decreased appetite, constipation, diarrhea, vomiting, pyrexia, hypoalbuminaemia, rash, arthralgia, edema peripheral, peripheral sensory neuropathy, pruritus, hyperglycemia, hypothyroidism, pneumonia, blood creatinine increased, hyperthyroidism, hypercholesteraemia, and interstitial lung disease (Supplementary Table S4). This evidence concerns the gene GPT and Pruritus.