The results demonstrated significant differences in pre-chemotherapy tumor size, pre-chemotherapy WBC, pre-chemotherapy NSE, pre-chemotherapy gastrin-releasing peptide precursor, pre-treatment FIB, post-cycle 2 D-dimer, post-cycle 2 gastrin-releasing peptide precursor, NSE change value, and WBC change value (P<0.05) (Table 4). Here, GRP is linked to neoplasm.