TNC and ulcer disease: Catechin can reduce the expression of interleukin-6 (IL-6) and IL-8 which function to overcome inflammation and increase the wound healing process by chemotactic for fibroblasts, accelerates their migration and stimulates deposition of tenascin, fibronectin, and collagen I during wound healingin vivo.21–24 The success of usingA. catechu in oral gel to heal the ulcers is in line with a previous study using ointment with 2% ethanolic extract on burns on the skin.10