This cognitive decline is associated with a reduction in brain density and volume of approximately 2.82% over a 6-month period (Teixeira et al., 2018), which impairs the connectivity and expression of neurotrophins involved in neuroplasticity, such as Brain-Derived Neurotrophic Factor (BDNF) (Leal et al., 2014; Li et al., 2021), compromising cognitive function (Tolea et al., 2015; Zahodne et al., 2013). This evidence concerns the gene BDNF and Mental deterioration.