FERMT2 and Alzheimer disease: SORL1, FERMT2, and apolipoprotein E (ApoE4) (Balcar et al., 2021; Mishra et al., 2022; Sullivan et al., 2019), are mainly expressed by astrocytes, and astrocytes undergo a series of morphological, molecular, and functional changes during the course of AD, suggesting that astrocytes play an important role in the pathogenesis of AD.