The most cited article published by Moloney AM et al. in 2010 elucidates that insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signaling are compromised in AD neurons and suggests that neurons that degenerate in AD may be resistant to IGF-1R/IR signaling (Moloney et al., 2010). Here, INSR is linked to Alzheimer disease.