Focusing on the top three studies, the most cited article (“Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling”) was published in the Neurobiology of Aging in 2010 and was cited 602 times(Moloney et al., 2010). This evidence concerns the gene IRS1 and early-onset autosomal dominant Alzheimer disease.