KCNN3 and necrotizing enterocolitis: Functional analysis using SEED classification revealed that pathways associated with type IV secretion systems, conjugative transfer, Enterobacterial common antigen (LPS O-antigen), quorum sensing in Yersinia, the L-rhamnose pathway, and iron transport systems—including ABC transporters and the Shikimate kinase SK3 cluster—were significantly enriched in infants with NEC compared to controls (Figures 7, 8).