PLK1 and breast carcinoma: AURKA and PLK1 are essential mitotic regulators that promote the G2/M transition and are often overexpressed in aggressive breast cancers (D'Assoro et al., 2015; Wang D. et al., 2017), while CDC25C facilitates CDK1 activation and has been associated with unchecked cell cycle progression in high-grade tumors (Topno et al., 2021).