Li et al. demonstrated that the initial factor of matrix stiffness enhances the activation of Piezo1 and the influx of Ca2+, which in turn inhibits the ubiquitination of HIF-1α, thereby facilitating the expression of pro-angiogenic factors VEGF, CXCL16, and IGFBP2, ultimately accelerating liver cancer angiogenesis.91 Here, PIEZO1 is linked to liver cancer.