PIEZO1 and liver cancer: Notably, hepatocyte-injury-released mechanical signals (e.g., ATP and HMGB1) can alter the stiffness of hepatic stellate cell microenvironment, activating their surface Piezo1; this transcellular signaling axis may constitute the critical bridge linking “hepatocyte injury to hepatic stellate cell activation” (see correlation analysis between sections hepatocytes and The regulation of liver tumors and liver cancer by Piezo1 ion channels).