PIEZO1 and liver cancer: ,93,94,95 Furthermore, in a high-stiffness Sprague Dawley (SD) rat orthotopic liver cancer model, a positive feedback regulatory loop involving stiff matrix/integrin β1/miR-625-5p/Piezo1 and COL1/stiffer matrix mediates the upregulation of Piezo1 expression by matrix stiffness.91