TRPV1 and hypertensive disorder: The central cardiovascular centers are mainly located in the medulla oblongata and hypothalamus, whose functional changes have been implicated in most forms of hypertension.[50, 51] In the present study, we reveal that RVMM receives direct innervation from hypothalamic histaminergic neurons and can be modulated by histamine to produce depressor and bradycardia responses via TRPV1 coupled to histamine H4R.