In addition, it stimulates renin release from juxtaglomerular cells and enhances tubular sodium and water reabsorption, collectively promoting blood pressure elevation and contributing to hypertension pathogenesis.[34, 56] Here we found that H4R activation‐excited RVMM neurons were GABAergic and induced inhibitory renal sympathetic outflow. The gene discussed is HRH4; the disease is Hypertension.