In addition, it stimulates renin release from juxtaglomerular cells and enhances tubular sodium and water reabsorption, collectively promoting blood pressure elevation and contributing to hypertension pathogenesis.[34, 56] Here we found that H4R activation‐excited RVMM neurons were GABAergic and induced inhibitory renal sympathetic outflow. This evidence concerns the gene HRH4 and hypertensive disorder.