SCN1A and epilepsy syndrome: Specifically, the heat-induced paralysis observed in these flies was reminiscent of heat-induced seizures observed in flies carrying pathogenic variants in the SCN1A-analogous fly gene para (paraGEFS+ or paraDS), which mimic SCN1A-associated epilepsy syndromes (Sun et al., 2012; Schutte et al., 2014; Roemmich et al., 2021).