Enterobacteriaceae, facultative anaerobes that thrive in inflammatory milieus, exacerbate colitis through LPS‐mediated activation of NF‐κB and other pro‐inflammatory pathways, leading to epithelial damage.[26] Sutterellaceae, frequently enriched during dysbiosis, may further disrupt microbial balance and perpetuate inflammation.[27]. The gene discussed is NFKB1; the disease is colitis.