Elevated levels of glycoprotein (GP) VI (p = 0.0012), Trem‐like transcript‐1 (TLT‐1) (p = 0.0248), platelet‐bound immunoglobulin (Ig) G (p < 0.0029), CitH3‐DNA complexes (p = 0.0022), TPO (p < 0.0001) and reduced platelet contribution to clot formation (p < 0.0001) were observed in primary ITP patients with bleeding and bruising symptoms. Here, TPO is linked to autoimmune thrombocytopenic purpura.