CircRNA can function as a scaffold to regulate the ubiquitination, SUMOylation, acetylation, and palmitylation of target proteins.[43, 44, 45, 46] The discovery of lactylation modification is of landmark significance.[47] As an important PTM, it allows a better understanding of the relationship between tumor metabolism and epigenetics and accelerates tumor metastasis and drug resistance; however, the limited research in this field warrants further expansion.[48, 49] Notably, CAF‐derived EV‐packaged circTAX1BP1 regulated the lactylation of VIRMA in CRC cells. The gene discussed is VIRMA; the disease is colorectal carcinoma.