TGFB1 and colorectal carcinoma: Furthermore, we demonstrated that CAF‐derived EV‐packaged circTAX1BP1 was internalized by CRC cells and promoted the transcription and paracrine signalling of TGF‐β; this maintained the TGF‐β signalling activation of ITAG11+ myCAFs and enhanced EV‐packaged circTAX1BP1 secretion to promote CRLM.