Paracrine TGF‐β of CRC cells specifically targets ITGA11+ myCAFs, activating the TGF‐β signalling pathway, which contributes to extracellular matrix remodeling and increases delivery of EV‐packaged circTAX1BP1, forming a positive feedback loop to promote CRLM. The gene discussed is ITGA11; the disease is colorectal carcinoma.