Furthermore, chromatin immunoprecipitation (ChIP) analysis revealed that treatment of CRC cells with exosomes mediating circTAX1BP1 (CRCcircTAX1BP1‐Evs) led to a significant increase in SP1 enrichment at site 1 of the TGF‐β promoter, whereas no such increase was observed at site 2 (Figure 6F,G). This evidence concerns the gene SP1 and colorectal carcinoma.