Furthermore, in CRC cells, AARS2 overexpression or lactate supplementation reversed the effects of CAF‐derived EVs transfected with circTAX1BP1 siRNA, restoring TGF‐β, p‐Smad2, p‐Smad3, and SP1 expression (Figure 5N,O; Figure S9H–K, Supporting Information). This evidence concerns the gene SMAD3 and colorectal carcinoma.