Taken together, our study elucidates a novel mechanism by which ITGA11+ myCAF‐derived EV‐packaged circTAX1BP1 recruits AARS2 to promote the lactylation modification of VIRMA at K1713 in colorectal tumor cells, enhances VIMRA‐K1713la‐dependent m6A modification of SP1 mRNA, and increases the transcriptional activation and paracrine signalling of TGF‐β in tumor cells. This evidence concerns the gene ITGA11 and neoplasm.