The term clinical remission is suitable in the following specific clinical scenarios: prolactin levels >1xULN, or uninterpretable prolactin levels (due to pregnancy, lactation, or comedication), without typical prolactinoma-related symptoms [ie, galactorrhea, loss of libido, subfertility, menstrual cycle disturbances, or erectile dysfunction (11)], with recovery of gonadal function, and without a certain remnant on MRI or treatment indication. This evidence concerns the gene PRL and erectile dysfunction.