In this study, we found higher protein and/or mRNA levels of DPPA4‐associated stem cell factors (SOX‐2, OCT‐4, KLF‐4, SNAIL‐1, and Nestin) in PAE male pituitaries (Chaudhary et al., 2025), suggesting that PAE similarly enhances estrogen‐induced pituitary tumor cell stemness in both sexes. This evidence concerns the gene POU5F1 and pituitary tumor.