The pattern of slower cognitive decline among individuals with overweight and obesity was not modified by adding any of the following as covariates to Model 2: a quadratic age term; the interaction of BMI category and DPP treatment arm; the interaction of BMI category and sex; the interaction of BMI category and APOE carrier status; the interaction of BMI category and race/ethnicity; and the SF6D summary score. The gene discussed is APOE; the disease is Obesity.