VEGFA and neoplasm: In one study, it has been described that the [89Zr]ranibizumab-PET signal is the sum of perfusion of the tracer into the tumor followed by binding to VEGF, and therefore a resultant of changed perfusion, mean vessel density and VEGF expression, reflecting VEGF biodistribution and bioavailability and allowing in vivo insight in overall tumor angiogenesis (Nagengast et al. 2011).