Although multiple melanocortin receptor agonists have been investigated, setmelanotide is currently the only MC4R agonist approved by the FDA for the treatment of specific genetic forms of obesity, including deficiencies in POMC, PCSK1, and LepR, as well as Bardet-Biedl syndrome (BBS) (135, 136). This evidence concerns the gene LEPR and obesity due to melanocortin 4 receptor deficiency.