NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Similarly, several activators of NRF2 signaling, including glucoraphanin and synthetic oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-imidazole, were shown to effectively attenuate HFD-induced lipid accumulation in wild-type, but not in Nrf2-deficient mice (42, 43), indicating the essential role of NRF2 in ameliorating obesity.