However, the expression pattern and functional relevance of SESTD1 in HCC are still unknown.<h4>Methods</h4>SESTD1 expression and its prognostic value in HCC were evaluated by parsing multiple databases, including the Cancer Genome Atlas (TCGA), GEO databases, and Kaplan-Meier (KM) plotter. Here, SESTD1 is linked to hepatocellular carcinoma.