While there is currently no direct experimental evidence of CREB5 binding to Ank3 in OLIGO, a previous study showed that oligodendrocyte–specific deletion of Ank3, which encodes glial AnkG, impairs axoglial interactions during aging and affects mouse behaviors, including motor learning, sociability, and depression (Ding et al. 2024). Here, CREB5 is linked to depressive disorder.