CCL20 and rheumatoid arthritis: These mechanisms include increased recruitment of DCs to sites of inflammation or lymph nodes, decreased production or release from the bone marrow,85 and impairments in the ability of DCs to migrate to draining lymph nodes.100,101 For instance, DCs within the RA synovium express elevated levels of CCR6, a receptor for CCL20, a chemokine active on both iDCs and Th17 cells.