Not only that, under inflammatory pathological conditions, infDCs can directly convert into OCs to induce severe bone destruction,95 which is promoted by protein citrullination and ACPA binding to DCs.77 The description of the DCs/OCs transdifferentiation is detailed below—part of Osteoclast. Similar to infDCs, cDCs contribute to the development and persistence of RA. This evidence concerns the gene PRTN3 and rheumatoid arthritis.