CCL20 and rheumatoid arthritis: Notably, CCL20 is located in proximity to iDCs within the synovium, suggesting its critical role in facilitating DCs recruitment into synovial tissue.100 On the other hand, DCs in the RA synovium demonstrate downregulation of CCL19 and CCL21, as well as their receptor CCR7, which is associated with impaired migration to lymph nodes.100,101