IGF2BP3 re-expressing mice displayed significantly higher counts for CD11b+, lineage− cells, and LSK (Lin− ckit+Sca1−) cells, including a potential leukemia-initiating cell (LIC) population,12,13 in both bone marrow and spleen (Figures 6K–6O and S8A–S8I, respectively). The gene discussed is IGF2BP3; the disease is leukemia.