NEDD4 and neoplasm: Finally, TCEB2 knockdown inhibited TNBC tumor growth and TNBC-induced M2 macrophage polarization in vivo.<h4>Conclusion</h4>TCEB2 upregulation promoted TNBC-induced M2 macrophage polarization to accelerate TNBC development by mediating Slit2 K63-ubiquitination degradation through interacting with NEDD4.